In this podcast with Regenerative Medicine Today, Dr. Schmuck discusses his research in cardio-regenerative medicine. This podcast was recorded in conjunction with the Journal of Immunology and Regenerative Medicine.
Eric G Schmuck, Sushmita Roy, Anisa Dhillon, Sydney Walker, Keith Spinal, Sophia Colevas, Tianhua Zhou, Gagan Chhabra, Yuming Liu, Md Abdul Kader Sagar, Charlie J Childs, John A Kink, Kevin W Eliceiri, Peiman Hematti, Amish N Raval. (2021). Cardiac fibroblasts and myofibroblasts express Sushi Containing Domain 2 and assemble a unique fibronectin rich matrix. Exp Cell Res, 15;399(2):112489.
Sushmita Roy, Keith Spinali, Eric G Schmuck, John A Kink, Peiman Hematti, Amish N Raval. (2020). Cardiac fibroblast derived matrix-educated macrophages express VEGF and IL-6, and recruit mesenchymal stromal cells. J Immunol Regen Med, 10:100033.
Zhang J, Tao R, Campbell KF, Carvalho JL, Ruiz E, Kim G, Schmuck EG, Raval AN et al. (2019). Functional cardiac fibroblasts derived from human pluripotent stem cells via second heart field progenitors. Nature Communications, 10:2238.
Schmuck EG, Hacker TA, Schreier DA, Chesler NC, Wang Z. (2019). Beneficial effects of mesenchymal stem cell delivery via a novel cardiac bioscaffold on right ventricles of pulmonary arterial hypertensive rats. American Journal of Physiology-Heart and Circulatory Physiology, 316(5), H1005-H1013.
Chamberlain CS, Clements AEB, Kink JA, Choi U, Baer GS, Halanski MA, Hematti P, Vanderby R. (2019). Extracellular Vesicle-Educated Macrophages Promote Early Achilles Tendon Healing. Stem Cells.
Schmuck, EG. Hematti, P. Raval, AN. (2018) Cardiac Extracellular Matrix: Fundamental Science to Clinical Applications. Springer. Advances in Experimental Medicine. ISBN: 978-3-319-97421-7.
Spinali KL, Schmuck EG. (2018). Natural Sources of Extracellular Matrix for Cardiac Repair. Advances in Experimental Medicine and Biology, 1098, 115-130.
Hematti P. (2018). Role of Extracellular Matrix in Cardiac Cellular Therapies. Advances in Experimental Medicine and Biology, 1098, 173-188.
Johnston PV, Duckers HJ, Raval AN, Cook TD, Pepine CJ. (2018). Not All Stem Cells Are Created Equal. Circulation Research, 123(8), 944-946
Raval AN, Cook TD, Duckers HJ, Johnston PV, Traverse JH, Abraham WT, Altman PA, Pepine CJ. (2018). The CardiAMP Heart Failure trial: A randomized controlled pivotal trial of high-dose autologous bone marrow mononuclear cells using the CardiAMP cell therapy system in patients with post-myocardial infarction heart failure: Trial rationale and study design. American Heart Journal, July(201), 141-148.
Raval AN. (2018) Clinical Trial Design for Investigational Cardio-Regenerative Therapy. Advances in Experimental Medicine and Biology, 1098, 199-211.
Konstam MA, Kiernan MS, Bernstein D, Bozkurt B, Jacob M, Kapur NK, Kociol RD, Lewis EF, Mehra MR, Pagani FD, Raval AN, Ward C. (2018). Evaluation and Management of Right-Sided Heart Failure: A Scientific Statement From the American Heart Association. American Heart Association Council on Clinical Cardiology; Council on Cardiovascular Disease in the Young; and Council on Cardiovascular Surgery and Anesthesia, 137(20), e578-e622.
Liu, S., De Castro, L. F., Jin, P., Civini, S., Ren, J., Reems, J. A., … Hematti, P., … McKenna, D. H. (2017). Manufacturing Differences Affect Human Bone Marrow Stromal Cell Characteristics and Function: Comparison of Production Methods and Products from Multiple Centers. Scientific Reports, 7.
Mesenchymal Stromal Cells: Translational Pathways to Clinical Adoption; Chapter 3: Delivery and Tracking for Cell Based Therapies, Eric G. Schmuck and Amish N. Raval. Elsevier 2017; ISBN: 978-0-12-802826-1
Bao X, Lian X, Hacker TA, Schmuck EG, Qian T, Bhute VJ, Han T, Shi M, Drowley L, Plowright A, et al. (2016). Long-term self-renewing human epicardial cells generated from pluripotent stem cells under defined xeno-free conditions. Nature Biomedical Engineering.
Braun, R. K., Koch, J. M., Hacker, T. A., Pegelow, D., Kim, J., Raval, A. N., … & Eldridge, M. (2016). Cardiopulmonary and histological characterization of an acute rat lung injury model demonstrating safety of mesenchymal stromal cell infusion. Cytotherapy, 18(4), 536-545.
Schmuck EG, Koch JM, Centanni JM, Hacker TA, Braun RK, Eldridge M, Hei DJ, Hematti P, Raval AN. (2016). Biodistribution and clearance of human Mesenchymal stem cells by quantitative three-dimensional cryo-imaging following intravenous infusion in a rat lung injury model. Stem Cells Translational Medicine, Jul 26. 2015-0379.
Lalit PA, Salick MR, Nelson DO, Squirrell JM, Shafer CM, Patel NG, Saeed I, Schmuck EG, Markandeya YS, Wong R, Lea MR, Eliceiri KW, Hacker TA, Crone WC, Kyba M, Garry DJ, Stewart R, Thomson JA, Downs KM, Lyons GE, Kamp TJ. (2016). Lineage Reprogramming of Fibroblasts to Proliferative Induced Cardiac Progenitor Cells by Defined Factors. Cell Stem Cell, 2016 Mar 3;18(3): 354-67.
Stem Cell and Gene Therapy for Cardiovascular Disease; Chapter 27: Scaffold-based Cell Delivery for Cardiac Repair, Lisle Blackbourn, Eric G. Schmuck, Amish N. Raval; Pages 327-339. Elsevier September 2016; ISBN: 978-0-12-801888-0.
Garlie N, Hacker TA, Schmuck EG, Koch JM, Khitha J, Raval AN, Choudhuri I. (2015). Feasibility of Atrial Delivery and Tracking of Stem Cells in a Porcine Model. Journal of Patient-Centered Research and Reviews, 2(4): 215.
Schmuck EG, Koch JM, Hacker TA, Hatt CR, Tomkowiak MT, Vigen KK, Hendren N, Zhao YQ, Li Z, Centanni JM, Hei DJ, Schwahn D, Kim J, Hematti P, Raval AN. (2015). Intravenous Followed by X-ray Fused with MRI-Guided Transendocardial Mesenchymal Stem Cell Injection Improves Contractility Reserve in a Swine Model of Myocardial Infarction. Journal of Cardiovascular Translational Research, 2015 Oct;8(7) 438-448.
Lalit, P. A., Hei, D. J., Raval, A. N., & Kamp, T. J. (2014). Induced Pluripotent Stem Cells for Post–Myocardial Infarction Repair. Circulation research, 114(8), 1328-1345.
Schmuck, E. G., Mulligan, J. D., Ertel, R. L., Kouris, N. A., Ogle, B. M., Raval, A. N., & Saupe, K. W. (2014). Cardiac fibroblast-derived 3D extracellular matrix seeded with mesenchymal stem cells as a novel device to transfer cells to the ischemic myocardium. Cardiovascular engineering and technology, 5(1), 119-131.
Raval AN, Schmuck EG, Tefera G, Leitzke C, Ark CV, Hei D, Centanni JM, de Silva R, Koch J, Chappell RG, Hematti P. (2014). Bilateral administration of autologous CD133+ cells in ambulatory patients with refractory critical limb ischemia: lessons learned from a pilot randomized, double-blinded, placebo-controlled trial. Cytotherapy.
King, S. N., Hanson, S. E., Chen, X., Kim, J., Hematti, P., & Thibeault, S. L. (2014). In vitro characterization of macrophage interaction with mesenchymal stromal cell‐hyaluronan hydrogel constructs. Journal of Biomedical Materials Research Part A, 102(3), 890-902.
Warrick JW, Young EW, Schmuck EG, Saupe KW, Beebe DJ. (2013). High-content adhesion assay to address limited cell samples. Integrative Biology: quantitative biosciences from nano to macro. 2013 Apr; 5(4): 720-7.
Cantu, D. A., Hematti, P., & Kao, W. J. (2012). Cell encapsulating biomaterial regulates mesenchymal stromal/stem cell differentiation and macrophage immunophenotype. Stem cells translational medicine, 1(10), 740-749.
Tomkowiak, M. T., Klein, A. J., Vigen, K. K., Hacker, T. A., Speidel, M. A., VanLysel, M. S., & Raval, A. N. (2011). Targeted transendocardial therapeutic delivery guided by mri—x‐ray image fusion. Catheterization and Cardiovascular Interventions, 78(3), 468-478.
Hanson, S. E., King, S. N., Kim, J., Chen, X., Thibeault, S. L., & Hematti, P. (2011). The effect of mesenchymal stromal cell–hyaluronic acid hydrogel constructs on immunophenotype of macrophages. Tissue Engineering Part A, 17(19-20), 2463-2471.
Kim, J., & Hematti, P. (2009). Mesenchymal stem cell–educated macrophages: A novel type of alternatively activated macrophages. Experimental hematology, 37(12), 1445-1453.
Raval, A. N., Kamp, T. J., & Hogle, L. F. (2008). Cellular therapies for heart disease: Unveiling the ethical and public policy challenges. Journal of molecular and cellular cardiology, 45(4), 593-601.
